Artigo Revisado por pares

Antialgal and Antifungal Activity of Natural Hydroxamic Acids and Related Compounds

1996; American Chemical Society; Volume: 44; Issue: 6 Linguagem: Inglês

10.1021/jf950345e

ISSN

1520-5118

Autores

Héctor R. Bravo, Waldo Lazo,

Tópico(s)

Cholinesterase and Neurodegenerative Diseases

Resumo

Natural hydroxamic acids and related compounds derived from 1,4-benzoxazin-3-one structures inhibited the growth of the alga Chlorella xanthella and the fungus Candida albicans. On the basis of structure−activity relationships the lipophilic character of the substituent in the aromatic ring and the electrophilic character of the hydroxamic function are suggested to be responsible for antialgal and antifungal activity, respectively. Keywords: Hydroxamic acids; Chlorella xanthella; Candida albicans; antialgal/antifungal activity

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