Metabolic and nutritional implications of valproic acid
1991; Elsevier BV; Volume: 11; Issue: 8 Linguagem: Inglês
10.1016/s0271-5317(05)80622-0
ISSN1879-0739
AutoresMichelle E. Nurge, Christine R. Anderson, Edric Bates,
Tópico(s)Epilepsy research and treatment
ResumoIdentifying drug-nutrient interactions is a significant concern to practitioners. Valproic acid, an antiepileptic drug, is frequently associated with hyperammonemia, and infrequently associated with fatal hepatotoxicity. Drug-nutrient interactions may contribute to the development of these effects, specifically carnitine, vitamin E and selenium. Currently, the literature suggests that carnitine supplementation may be a viable consideration for individuals on valproic acid therapy.
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