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ADRENOGENITAL SYNDROME WITH ASSOCIATED EPISODES OF HYPOGLYCEMIA

1951; Oxford University Press; Volume: 11; Issue: 11 Linguagem: Inglês

10.1210/jcem-11-11-1395

1945-7197

Forrest P. White, Lee Sutton,

Hormonal Regulation and Hypertension

THE adrenogenital syndrome is a type of hyperadrenocorticism characterized by excess production of adrenal androgens. When it occurs congenitally it is due to hyperplasia of the adrenal glands, and is manifested as pseudohermaphrodism in females and macrogenitosomia praecox in males. Wilkins (1) has recently described the syndrome and collected 99 such cases from the literature and his own observations. A postnatal variety of adrenogenital syndrome also occurs, and is caused usually by adrenal tumors. Forty-one cases are mentioned by Wilkins (1). Wilkins, Fleischmann, and Howard (2) and Butler, Ross and Talbot (3) in 1939 first described cases of adrenogenital syndrome in which Addisonian symptoms of acute adrenal insufficiency occurred. Zuelzer and Blum (4) recently collected 17 such cases from the literature and added 4 of their own. Since their review, 2 cases have been reported by DeJong and Schaberg (5), 1 case by Chenoweth (6), and 1 case by the New York Hospital group (7). At least 3 and possibly more of 13 cases reported by Allibone, Baar, and Cant (8) as “interrenal syndrome” were probably due to the same condition.