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Association between the −794 (CATT) 5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population

2014; Hindawi Publishing Corporation; Volume: 2014; Linguagem: Inglês

10.1155/2014/704854

2314-8861

Emmanuel Valdés‐Alvarado, José Francisco Muñoz‐Valle, Yeminia Valle, Elena Sandoval‐Pinto, Ilian Janet García-González, Angélica Valdez-Haro, Ulises De la Cruz-Mosso, Héctor Enrique Flores-Salinas, Jorge Ramón Padilla‐Gutiérrez,

Nuclear Receptors and Signaling

The macrophage migration inhibitory factor ( MIF ) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS). MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate. The aim of this study was to investigate the association between the −794 C A T T 5 – 8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population. This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS). The −794 C A T T 5 – 8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique. The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%). The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P = 0.03 ). We conclude that the 6/7 genotype of the MIF −794 C A T T 5 – 8 polymorphism is associated with susceptibility to ACS in a western Mexican population.