Portal de Periódicos da CAPES

Lipopolissacarídeo (LPS): ativador e regulador da transcrição gênica via fator de transcrição NFKB

2010; Volume: 4; Linguagem: Inglês

10.7594/revbio.04.08

1984-5154

Sanseray da Silveira Cruz‐Machado,

Aquaculture disease management and microbiota

LPS is the main component from membrane surface of gram-negative bacteria known as a potent activator of immune response. This effect is mediated mainly through the NFKB signaling pathway. NFKB remains inactivated in cytoplasm due to interactions with repressor proteins and the triggering of LPS receptors allows NFKB dimmers to translocate to the nucleus and to promote gene transcription. Besides the response activated by LPS being well understood, the regulatory steps of this response remain obscure. Is this review, we will describe how LPS activates NFKB pathway and the main steps that regulate this signaling with focus on the regulation of gene expression.