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Allantoate hydrolysis by allantoate amidohydrolase

1970; Elsevier BV; Volume: 136; Issue: 1 Linguagem: Inglês

10.1016/0003-9861(70)90351-6

1096-0384

Chris van der Drift, F. E. de Windt, Godfried D. Vogels,

Folate and B Vitamins Research

The degradation of allantoate by allantoate amidohydrolase from Streptococcus allantoicus resulted in the production of 1 mole of carbon dioxide, 2 moles of NH3, and probably 1 mole of (−)-ureidoglycolate per mole of allantoate. Ureidoglycine was an intermediate and presumably also a substrate for allantoate amidohydrolase. A nonenzymic transamination reaction of ureidoglycine and glyoxylate resulted in the formation of glycine and oxalurate. The enzymic and nonenzymic reactions which take place during degradation of allantoate are discussed.