Effect of mucoactive/mucolytic drugs on the integrity of the gastric mucosal barrier. A preliminary comparison between s-carboxymethylcysteine lysine salt and n-acetylcysteine
1994; Elsevier BV; Volume: 55; Issue: 4 Linguagem: Inglês
10.1016/s0011-393x(05)80534-x
ISSN1879-0313
AutoresO. Sangaletti, Marco Petrillo, F. Santalucia, Haixing Zhu, E. Trapé, G. Bianchi Porro,
Tópico(s)Gastrointestinal motility and disorders
ResumoAbstract Simultaneous measurement of gastric pH and the gastric mucosa potential difference (GPD) before and after treatment was performed to evaluate the effect of S-carboxymethylcysteine lysine salt (SCMC-Lys) and N-acetylcysteine (NAC) on the integrity of the gastric mucosal barrier. Six dyspeptic patients were treated in a double-blind, double-dummy, crossover study. The drugs were administered orally in a single dose of 2.7 g granulated SCMC-Lys (daily therapeutic dose) and a single dose of 200 mg NAC (the therapeutic dosage of NAC is 200 mg BID or TID). The pH values before and after treatments were normal. SCMC-Lys induced a less pronounced change in GPD parameters than NAC: the time during which GPD values were below base-line values was shorter after SCMC-Lys treatment (mean, 70.8 min ± 39.6) than after NAC treatment (mean, 82.0 min ± 34.7); the maximum change of GPD was significantly lower after SCMC-Lys treatment (mean, 17.16 mV ± 4.7) than after NAC treatment (mean, 24.0 mV ± 6.2; P t test); and the Reiz index, a predictive index of mucosal damage, was lower after SCMC-Lys treatment (mean, 20.77 ± 27.78) than after NAC treatment (mean, 31.85 ± 27.09). The results show that NAC induced changes on the gastric mucosal barrier as evaluated by GPD, whereas SCMC-Lys did not.
Referência(s)