Portal de Periódicos da CAPES

Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

1999; Thieme Medical Publishers (Germany); Volume: 65; Issue: 4 Linguagem: Inglês

10.1055/s-1999-13994

1439-0221

Jadwiga Jodynis‐Liebert, Marek Murias, Ełżbieta Błoszyk,

Plant Toxicity and Pharmacological Properties

Seven sesquiterpene lactones isolated from Helenium aromaticum: helenalin, mexicanin I, linifolin A, geigerinin, and from Telekia speciosa: 6α-hydroxy-2,3-dihydroaromaticin, asperilin, telekin have been tested for their hydroxyl radical scavenging activity and effect on lipid peroxidation. All compounds were found to be potent hydroxyl radical scavengers but did not affect lipid peroxidation in vitro. In vivo they exerted pro-oxidative properties and caused glutathione level depletion and elevation in glutathione peroxidase activity.