The effects of syringe plunger design on drug delivery during vertical displacement of syringe pumps
2000; Wiley; Volume: 55; Issue: 11 Linguagem: Inglês
10.1046/j.1365-2044.2000.01550.x
ISSN1365-2044
AutoresMarkus Weiß, J. Fischer, Tobias Neff, O. Baenziger,
Tópico(s)Embedded Systems and FPGA Applications
ResumoFluid delivery from four types of commercially available 50‐ml syringes was measured using an electronic balance at an infusion rate of 1 ml.h −1 . Retrograde aspiration volume and zero‐drug delivery time were recorded after lowering the syringe pump by 50 cm. Syringe compliance was calculated from the volume of bolus released after occlusion at 100 mmHg. Zero‐drug delivery times differed significantly between syringes, ranging from [mean (SD)] 3.26 (0.40) min to 6.38 (0.56) min ( F = 55.5, d.f. = 3/20, p < 0.0001). Syringe compliance correlated well with aspiration volume (Pearson r 2 = 0.92, p < 0.001) and zero‐drug delivery time ( r 2 = 0.90, p < 0.001). Syringe design affected the internal syringe compliance. All syringes were associated with potentially relevant zero‐drug delivery times after moderate vertical displacement. To minimise this risk, vertical displacement of syringe pumps delivering highly vasoactive drugs should be avoided.
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