APV, an N-methyl-d-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats
1988; Elsevier BV; Volume: 463; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(88)90538-0
ISSN1872-6240
AutoresL. Stan Leung, Kathy A. Desborough,
Tópico(s)Receptor Mechanisms and Signaling
Resumo2-Aminophosphonovaleric acid (APV), an N-methyl-d-aspartate (NMDA) receptor antagonist, was infused into the lateral ventricles of behaving rats. A 10 or 20 μg dose of APV attenuated the hippocampal θ rhythm and the θ phase-shift at the apical dendrites of hippocampal CA1 region. A selective suppression of the atropine-sensitive θ rhythm was suggested.
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