Primary Peripheral PNET/Ewing's Sarcoma of the Dura: a Clinicopathologic Entity Distinct from Central PNET
2002; Elsevier BV; Volume: 15; Issue: 6 Linguagem: Inglês
10.1038/modpathol.3880585
ISSN1530-0285
AutoresFranceska Dedeurwaerdere, Caterina Giannini, Raf Sciot, Brian P. Rubin, Giorgio Perilongo, L Borghi, Maria Luisa Ballotta, Erwin M. J. Cornips, Anouk Demunter, Brigitte Maes, Angelo Paolo Dei Tos,
Tópico(s)Lymphoma Diagnosis and Treatment
ResumoAbstract We describe two cases of peripheral primitive neuroectodermal tumor–Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase–polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.
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