RNAi: antiviral therapy against dengue virus
2013; Medknow; Volume: 3; Issue: 3 Linguagem: Inglês
10.1016/s2221-1691(13)60057-x
ISSN2588-9222
AutoresSobia Idrees, Usman Ali Ashfaq,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoDengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
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