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BIBTEX RIS

Determinação simultânea de olanzapina e cloridrato de fluoxetina em formulações farmacêuticas por espectrofotometria derivativa

2012; Brazilian Chemical Society; Volume: 35; Issue: 3 Linguagem: Inglês

10.1590/s0100-40422012000300033

ISSN

1678-7064

Autores

Jacira Izidório de Moura, Graziella Ciaramella Moita,

Tópico(s)

Analytical Methods in Pharmaceuticals

Resumo

FORMULATIONS BY DERIVATIVE SPECTROPHOTOMETRY.Simple, sensitive and accurate spectrophotometric derivative methods were developed for the simultaneous determination of olanzapine and fluoxetine hydrochloride in pharmaceutical formulations by derivative spectrophotometry.On all orders of derivative studied, the linear response range was 10 to 60 mg L -1 , with limit of quantitation (LoQ) ranging from 0.73 to 1.49 mg L -1 for fluoxetine hydrochloride and from 0.18 to 0.96 mg L -1 for olanzapine.The best orders for derivative analyses showed recoveries ranging from 99 to 103% and from 98 to 100%, and inter-day accuracy ≤ 2.1% and ≤ 2.8%, for fluoxetine hydrochloride and olanzapine, respectively.

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