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Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993; American Association for the Advancement of Science; Volume: 259; Issue: 5097 Linguagem: Inglês

10.1126/science.8438156

1095-9203

Cheryl L. Willman, Cordelia E. Sever, Maria G. Pallavicini, Hisashi Harada, Nobuyuki Tanaka, Marilyn L. Slovak, Hitomi Yamamoto, Kenji Harada, T C Meeker, Alan F. List, Tadatsugu Taniguchi,

Cancer-related Molecular Pathways

One of the most frequent cytogenetic abnormalities in human leukemia and myelodysplasia is an interstitial deletion within chromosome 5q. A tumor suppressor gene has been hypothesized to lie in 5q31, the smallest commonly deleted region. IRF-1 , a gene whose product manifests anti-oncogenic activity, was mapped to 5q31.1. IRF-1 lies between IL-5 and CDC25C and is centromeric to IL-3 and GM-CSF . Among these genes, only IRF-1 was consistently deleted at one or both alleles in 13 cases of leukemia or myelodysplasia with aberrations of 5q31. Inactivating rearrangements of one IRF-1 allele, accompanied by deletion of the second allele, were also identified in one case of acute leukemia. Thus, IRF-1 may be a critically deleted gene in human leukemia and myelodysplasia.