Nanomolar concentrations of propranolol inhibit GABA-stimulated benzodiazepine binding to rat cerebral cortex
1982; Elsevier BV; Volume: 29; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(82)90346-9
ISSN1872-7972
Autores Tópico(s)Neuroscience and Neural Engineering
ResumoThe influence of propranolol on GABA-stimulated [3H]diazepam binding in the rat cerebral cortex was investigated. Maximum potentiation of GABA-stimulated binding (20.6 ± 4.5%, P < 0.05) was observed at 100 μM propranolol, whilst maximum inhibition (32.5 ± 2.5%, P < 0.01) was observed at 1 nM propranolol. Low concentrations (1 nM) of (+)-propranolol were observed to be equipotent with (±)-propranolol in shifting the dose-response curve of GABA-stimulated [3H]diazepam binding by approximately 12 log unit. The phenomenon does not therefore show the stereospecificity observed towards either β-adrenergic receptors or 5-hydroxytryptamine receptors.
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