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Protein folding on the ribosome

2010; Elsevier BV; Volume: 20; Issue: 1 Linguagem: Inglês

10.1016/j.sbi.2010.01.005

1879-033X

Lisa D. Cabrita, Christopher M. Dobson, John Christodoulou,

Protein Structure and Dynamics

In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. In this article we discuss recent approaches designed to reveal how such folding occurs and review our current knowledge of this complex self-assembly process.