Regeneration of various cellular components in rat livers after subtotal hepatectomy
1958; Elsevier BV; Volume: 77; Issue: 1 Linguagem: Inglês
10.1016/0003-9861(58)90049-3
ISSN1096-0384
AutoresJulien L. Van Lancker, D.G. Sempoux,
Tópico(s)Liver Disease Diagnosis and Treatment
ResumoThe nitrogen, deoxyribonucleic acid (DNA), number of nuclei, and the activities of cytochrome oxidase, acid phosphatase, and glucose-6-phosphatase were determined in the regenerating livers, 6, 12, 24, 36, 48, and 72 hr. after subtotal hepatectomy. It was found that the components under investigation returned to the normal values at parallel rates, excepting the DNA and the number of nuclei. The DNA per liver was unchanged during the 12 first hours following hepatectomy but increased rapidly after this time period. The number of nuclei remained unchanged during the first 24 hr. after the operation and then recovered their normal values at a relatively slow rate. This resulted in a marked increase in DNA and cytoplasmic enzymes per nucleus, reaching a maximum 24 hr. after hepatectomy.
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