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Ligand recognition during thymic development and γδ T cell function specification

2010; Elsevier BV; Volume: 22; Issue: 4 Linguagem: Inglês

10.1016/j.smim.2010.04.002

1096-3618

Christina Meyer, Xun Zeng, Yueh‐hsiu Chien,

Immunotherapy and Immune Responses

gammadelta T cells develop in the thymus before entering the periphery. Recent work suggests that thymic development does little to constrain gammadelta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-naïve gammadelta T cells produce IL-17, ligand-experienced cells make IFN-gamma and those that are strongly self-reactive make IL-4. Importantly, gammadelta T cells are able to make cytokines immediately upon TCR engagement. These characteristics allow gammadelta T cells to initiate an acute inflammatory response to pathogens and to host antigens revealed by injury. These advances warrant a fresh look at how gammadelta T cells may function in the immune system.