Effects of dibutyryl-3',5'-cyclic adenosine monophosphate, phosphodiesterase inhibitors and prostaglandin E1 on compound 4880-induced histamine release from rat peritoneal mast cells invitro
1971; Elsevier BV; Volume: 20; Issue: 9 Linguagem: Inglês
10.1016/0006-2952(71)90228-0
ISSN1873-2968
AutoresLarry J. Loeffler, Walter Lovenberg, Albert Sjoerdsma,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoThe release of histamine from rat peritoneal mast cells by compound 4880 was inhibited by high concentrations of 6N-O-dibutyryladenosine-3',5'-cyclic-monophosphate (DB-c-AMP). Several other adenine nucleotides were ineffective at comparable concentrations. The histamine release promoted by compound 4880 was also inhibited by prostaglandin E1 (PGE1) and the phosphodiesterase inhibitors, theophylline, reserpine, diethylaminoethylreserpine and perphenazine. With the exception of theophylline, these inhibitors themselves produced a less dramatic release of histamine. Although the concentrations required for inhibition of histamine release are quite high, the data obtained for DB-c-AMP, phosphodiesterase inhibitors and PGE1 can be viewed as circumstantial evidence in support of a role for c-AMP in the histamine release process of the mast cell.
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