Granulysin: a lethal weapon of cytolytic T cells
1999; Elsevier BV; Volume: 20; Issue: 9 Linguagem: Inglês
10.1016/s0167-5699(99)01449-8
ISSN1355-8242
AutoresSteffen Stenger, Jean-Pierre Rosat, Barry R. Bloom, Alan M. Krensky, Robert L. Modlin,
Tópico(s)Invertebrate Immune Response Mechanisms
ResumoCD8+ T cells protect against infection from intracellular bacteria and parasites by lysing infected targets. Here, a novel mechanism is discussed in which CD8+ cytolytic T cells directly destroy intracellular pathogens by releasing an antimicrobial protein, granulysin, from cytotoxic granules.
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