Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent
2004; American Chemical Society; Volume: 4; Issue: 2 Linguagem: Inglês
10.1021/nl035124z
ISSN1530-6992
AutoresKinneret Keren, Rotem Berman, Erez Braun,
Tópico(s)RNA Interference and Gene Delivery
ResumoLocalization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.
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