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Hereditary pulmonary alveolar proteinosis. Could it be triggered by Mycoplasma pneumoniae pneumonia?

2012; Elsevier BV; Volume: 107; Issue: 1 Linguagem: Inglês

10.1016/j.rmed.2012.07.005

1532-3064

Mikel Santiago‐Burruchaga, Rafael Zalacain-Jorge, José Manuel Álvarez‐Martínez, Jose Mari Arguinzoniz-Marzana, Itziar Pocheville-Guruzeta, Miguel Angel Vazquez-Ronco, Armando Gozalo-García, Carlos Vázquez-Cordero,

Medical Imaging and Pathology Studies

We present a three-year-old girl with respiratory failure due to hereditary pulmonary alveolar proteinosis caused by abnormal alpha chain of the granulocyte-macrophage colony-stimulating factor receptor. Both the patient and an asymptomatic seven-year-old sister were homozygous for the same mutation in CSF2RA. We speculate that the Mycoplasma pneumoniae pneumonia might have triggered the clinical presentation. While a good response to serial partial lung lavage was noticed, the ultimate outcome is uncertain.