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A C-terminal aldehyde insect kinin analog enhances inhibition of weight gain and induces significant mortality in Helicoverpa zea larvae

2003; Elsevier BV; Volume: 24; Issue: 10 Linguagem: Inglês

10.1016/j.peptides.2003.06.008

1873-5169

R.J. Nachman, Geoffrey M. Coast, Céline Douat, Jean-Alain Fehrentz, Krzysztof Kaczmarek, Janusz Zabrocki, Nan W. Pryor, Jean Martínez,

Insect-Plant Interactions and Control

The first reported examples of C-terminal aldehyde analogs of an insect neuropeptide are described. They are hexapeptide insect kinin analogs Boc-VFFPWG-H and Fmoc-RFFPWG-H. Activity observed for these modified analogs in an in vitro insect diuretic assay confirms that the C-terminal aldehyde group is tolerated by an insect kinin receptor. The two analogs demonstrate greatly enhanced activity over standard C-terminal amide insect kinins in a larval weight gain inhibition assay in the corn earworm Helicoverpa zea. Treatment with Boc-VFFPWG-H led to significant increases in larval mortality at doses of 500 pm (45%) and 5 nm (67%). Boc-VFFPWG-H represents a lead analog in the development of novel, environmentally friendly pest insect management agents based on the insect kinin class of neuropeptides.