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Anticancer activity of organometallic compounds. 3. The reaction of dimethyltin dichloride with nucleosides under biologically relevant conditions

1986; Elsevier BV; Volume: 125; Issue: 2 Linguagem: Inglês

10.1016/s0020-1693(00)82088-5

1873-3255

Christine J. Cardin, Abhijit Roy,

Organometallic Compounds Synthesis and Characterization

This paper reports the reaction of SnMe2Cl2 with adenosine, guanosine and inosine in aqueous solution at pH 4.5. The nucleosides give probably polymeric species in which there is monodentate coordination to O2′ of the ribose ring as indicated by 80 MHz PMR.