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Boundary functions in the control of gene expression

1991; Elsevier BV; Volume: 7; Issue: 10 Linguagem: Inglês

10.1016/0168-9525(91)90424-o

1362-4555

Joel C. Eissenberg, Sarah C. R. Elgin,

Cancer-related gene regulation

Recent experiments using stably transformed genes in mouse and Drosophila have demonstrated that elimination of euchromatic position effects can be used as a functional assay for domain boundaries. These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging.