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Enantioseparation through Supercritical Fluid Simulated Moving Bed (SF-SMB) Chromatography

2001; American Chemical Society; Volume: 40; Issue: 21 Linguagem: Inglês

10.1021/ie000959v

1520-5045

Félicie Denet, Willy Hauck, R. M. Nicoud, Orazio Di Giovanni, Marco Mazzotti, Jean‐Noël Jaubert, Massimo Morbidelli,

Crystallization and Solubility Studies

In this work, the first enantioseparation in a SF-SMB unit, i.e., a simulated moving bed (SMB) operated under supercritical conditions, is reported. Complete separation of the two enantiomers of tetralol was achieved both in the pressure-gradient mode (where a pressure gradient is imposed along the four sections of the unit) and in the isocratic mode (where the pressure is kept constant). However, an almost 3-fold increase in productivity could be achieved in the pressure-gradient rather than the isocratic mode. The obtained results are explained and rationalized using recently developed design criteria for SMBs, the so-called "triangle theory", which have been properly extended to allow for different pressure values in the different sections of the unit.