Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection
2015; American Association for the Advancement of Science; Volume: 347; Issue: 6222 Linguagem: Inglês
10.1126/science.aaa1300
ISSN1095-9203
AutoresMauro Gaya, Angelo Castello, Beatriz Montaner, Neil C. Rogers, Caetano Reis e Sousa, Andreas Bruckbauer, Facundo D. Batista,
Tópico(s)Immunotherapy and Immune Responses
ResumoThe layer of macrophages at the subcapsular sinus (SCS) captures pathogens entering the lymph node, preventing their global dissemination and triggering an immune response. However, how infection affects SCS macrophages remains largely unexplored. Here we show that infection and inflammation disrupt the organization of SCS macrophages in a manner that involves the migration of mature dendritic cells to the lymph node. This disrupted organization reduces the capacity of SCS macrophages to retain and present antigen in a subsequent secondary infection, resulting in diminished B cell responses. Thus, the SCS macrophage layer may act as a sensor or valve during infection to temporarily shut down the lymph node to further antigenic challenge. This shutdown may increase an organism's susceptibility to secondary infections.
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