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A common anti-DNA antibody idiotype and anti-phospholipid antibodies in sera from patients with schistosomiasis and filariasis with and without nephritis

1989; Elsevier BV; Volume: 2; Issue: 6 Linguagem: Inglês

10.1016/0896-8411(89)90006-1

1095-9157

Mark Thomas, Geoff K Frampton, David Isenberg, Yehuda Shoenfeld, A Akinsola, Maher Fouad Ramzy, J. Lilleywhite, D G Williams,

Complement system in diseases

The serum concentration of a public idiotype (166 ID), originally identified on a human hybridoma-derived monoclonal anti-DNA antibody, was raised in patients with S. mansoni and filariasis with or without nephritis, compared to patients with S. haematobium (in which nephritis does not occur) or idiopathic nephritis not associated with infection. There was no significant difference in 166 ID levels between patients with or without renal disease, whether associated with S. mansoni or filarial infection. The 166 ID-positive antibodies did not bind to native or denatured DNA, using competitive fluid-phase inhibition studies. Anti-cardiolipin antibody (ACA) concentration was increased in patients with either S. mansoni or filarial infection. In filariasis, both IgG and IgM ACA isotypes were elevated, irrespective of the presence of nephritis. In S. mansoni infection, IgA ACA were limited to patients with renal disease, and IgG ACA isotype to patients without overt nephritis. Both isotypes of anti-cardiolipin antibody correlated with levels of the 166 ID in patients with S. mansoni or filariasis. The 166 idiotype was therefore a feature of chronic helminthic infection, but was not related to anti-DNA antibody levels or specificity. The occurrence of nephritis as a complication of these infections was not related to the prevalence of the 166 idiotype.