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Exhaled carbon monoxide as a marker for evaluating smoking abstinence in a Brazilian population sample

2007; Springer Nature; Volume: 16; Issue: 1 Linguagem: Inglês

10.3132/pcrj.2007.00008

1475-1534

José Miguel Chatkin, Leandro Genehr Fritscher, Carolina de Camargo Abreu, Daniela Cavalet-Blanco, Gustavo Chatkin, Mário Bernardes Wagner, Carlos Cézar Fritscher,

Neuroscience of respiration and sleep

Exhaled carbon monoxide (COExh) measurement is used to confirm smoking status in smoking cessation programs, but the cut-off level is still a matter for discussion. The objective of this study was to compare COExh levels in smokers and non-smokers to validate the method in a Brazilian population and to estimate the probability of the patient still smoking according to different cut-off points. In this cross-sectional study we studied non-atopic Caucasian volunteers with no respiratory infection or steroid therapy in the preceding four weeks. pregnancy; breast feeding; age 65 years old; and subjects not signing informed consent. Participants filled out a questionnaire and had their COExh levels measured. Bayes' theorem was used to calculate the post-test probabilities. We included 393 subjects of whom 239 (61%) were smokers. The mean COExh was 14.7 +/− 9.4ppm and 4.3 +/− 2.5ppm (p 11ppm, when the likelihood ratio became 63.80 (95%CI 16.1–253.1). In smoking cessation practice, a likelihood ratio approach may be useful to determine the probability that an individual is still smoking according to various COExhCOExh cut-off points instead of using a fixed value for all patients.