Neurotoxic mechanisms of fish-borne methylmercury
2002; Elsevier BV; Volume: 12; Issue: 2 Linguagem: Inglês
10.1016/s1382-6689(02)00028-5
ISSN1872-7077
Autores Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoMethylmercury (MeHg) epidemics and studies in fish-eating populations have provided invaluable insights into the neurotoxic sequelae of MeHg exposure. MeHg is a ubiquitous environmental contaminant, and its accumulation in the food chain will continue to pose health risks given anthropogenic and natural contamination. This review briefly addresses recent epidemiological data associated with exposure to MeHg in fish-eating populations, identifies mechanisms of MeHg transport into the central nervous system (CNS), and discusses various theories on cellular processes afflicted by MeHg, which most certainly include astrocytic failure to maintain the composition of the extracellular fluid.
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