Synthese von Peptid‐Zwischenprodukten für den Aufbau eines corticotrop wirksamen Nonadecapeptids. II. Derivate des L ‐Seryl‐ L ‐tyrosyl‐ L ‐serins
1961; Wiley; Volume: 44; Issue: 1 Linguagem: Inglês
10.1002/hlca.19610440122
ISSN1522-2675
Autores Tópico(s)Click Chemistry and Applications
ResumoThe synthesis of t‐butyloxycarbonyl derivatives of L ‐seryl‐ L ‐tyrosyl‐ L ‐serine and L ‐seryl‐ L ‐tyrosyl‐ L ‐seryl‐ L ‐methionine is described. The azide method involving the conversion of a hydrazide into the corresponding azide under acidic conditions was found to be applicable, under carefully selected conditions, to the synthesis of t‐butyloxycarbonyl peptide derivatives in spite of the sensitivity of the protecting group toward strongly acidic reagents.
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