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Intermolecular radical CC bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides

1992; Elsevier BV; Volume: 33; Issue: 19 Linguagem: Inglês

10.1016/s0040-4039(00)79047-2

1873-3581

Françoise Debart, Jean‐Jacques Vasseur, Yogesh S. Sanghvi, P. Dan Cook,

CRISPR and Genetic Engineering

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-Ch2NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction. The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.