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Recent discovery and development of selective protein kinase C inhibitors

1996; Elsevier BV; Volume: 1; Issue: 10 Linguagem: Inglês

10.1016/s1359-6446(96)80010-9

1878-5832

Haitao Hu,

Enzyme function and inhibition

Evidence for inappropriate activation of protein kinase C (PKC) in a variety of human disease processes suggests that PKC represents a novel cellular target for development of therapeutic agents. A number of potent and selective PKC inhibitors identified recently have demonstrated potential therapeutic applications in both in vitro and in vivo studies. This article reviews the recent development of some of these PKC inhibitors based on their chemical class.