Variables of patient‐controlled analgesia 4: the relevance of bolus dose size to supplement a background infusion
1990; Wiley; Volume: 45; Issue: 8 Linguagem: Inglês
10.1111/j.1365-2044.1990.tb14382.x
ISSN1365-2044
AutoresHarry Owen, M. T. Kluger, John L. Plummer,
Tópico(s)Anesthesia and Sedative Agents
ResumoSummary A range of self‐administered demand doses of morphine (0.4, 0.7 and 1.0 mg) were prescribed to supplement a fixed‐rate infusion (1.5 mg/hour) for pain control after gynaecological surgery. The number of demand doses administered during the first 25 hours after surgery was not significantly influenced by size of demand dose. There was a significant linear trend to increasing amount of demanded morphine with increasing bolus size. These results cast doubt on the usefulness of the concept of a minimum effective analgesic concentration of morphine.
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