Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease
1998; Wiley; Volume: 74; Issue: 2 Linguagem: Inglês
10.1002/(sici)1096-8628(19970418)74
ISSN1096-8628
AutoresPaola Costa, Harvey Checkoway, Drew Levy, Terri Smith‐Weller, Gary M. Franklin, Phillip D. Swanson, Lucio G. Costa,
Tópico(s)Nuclear Receptors and Signaling
ResumoAmerican Journal of Medical GeneticsVolume 74, Issue 2 p. 154-156 Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease Paola Costa, Paola Costa Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorHarvey Checkoway, Corresponding Author Harvey Checkoway Department of Environmental Health, University of Washington, Seattle, Washington Department of Epidemiology, University of Washington, Seattle, WashingtonDepartment of Environmental Health, University of Washington, Box 357234, Seattle, WA 98195-7234Search for more papers by this authorDrew Levy, Drew Levy Department of Epidemiology, University of Washington, Seattle, WashingtonSearch for more papers by this authorTerri Smith-Weller, Terri Smith-Weller Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorGary M. Franklin, Gary M. Franklin Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorPhillip D. Swanson, Phillip D. Swanson Department of Neurology, University of Washington School of Medicine, Seattle, WashingtonSearch for more papers by this authorLucio G. Costa, Lucio G. Costa Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this author Paola Costa, Paola Costa Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorHarvey Checkoway, Corresponding Author Harvey Checkoway Department of Environmental Health, University of Washington, Seattle, Washington Department of Epidemiology, University of Washington, Seattle, WashingtonDepartment of Environmental Health, University of Washington, Box 357234, Seattle, WA 98195-7234Search for more papers by this authorDrew Levy, Drew Levy Department of Epidemiology, University of Washington, Seattle, WashingtonSearch for more papers by this authorTerri Smith-Weller, Terri Smith-Weller Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorGary M. Franklin, Gary M. Franklin Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this authorPhillip D. Swanson, Phillip D. Swanson Department of Neurology, University of Washington School of Medicine, Seattle, WashingtonSearch for more papers by this authorLucio G. Costa, Lucio G. Costa Department of Environmental Health, University of Washington, Seattle, WashingtonSearch for more papers by this author First published: 24 October 2002 https://doi.org/10.1002/(SICI)1096-8628(19970418)74:2 3.0.CO;2-UCitations: 29AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Monoamine oxidase B (MAO-B) is an enzyme that has relevance for Parkinson disease (PD) because of its roles in catabolizing dopamine and potentially activating exogenous neurotoxicants. A polymorphism of the gene encoding MAO-B has been identified as a single base change (A or G) in intron 13 of the X chromosome. The A allele was previously associated with an approximately twofold risk of PD. The present study compared A and G allele frequencies between newly diagnosed idiopathic PD cases and a control group free of neurodegenerative diseases. All study subjects were Caucasian. Cases were 37 men and 25 women, age 37–80 years; controls were 50 men and 29 women, age 45–82 years. MAO-B genotype was determined by the allele-specific polymerase chain reaction on DNA extracted from peripheral lymphocytes. In complete contrast to previous studies, elevated risks were detected with the G allele. The age-adjusted odds ratio for the G allele in males was 1.87 ((95% confidence interval) 0.78–4.47). Among females the age-adjusted odds ratios were 5.00 ((95% confidence interval) 1.13–22.1) for the GA genotype and 5.60 ((95% confidence interval) 1.01–30.9) for the GG genotype. These findings, although of limited statistical precision, suggest that the G allele of this MAO-B polymorphism may relate to PD risk. Am. J. Med. Genet. 74:154–156, 1997. © 1997 Wiley-Liss, Inc. References Chiba, K, Trevor A, Castagnoli N (1984): Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 120: 574–578. 10.1016/0006-291X(84)91293-2 CASPubMedWeb of Science®Google Scholar Fowler, JS, Volkow ND, Wang G-J, Pappas N, Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I, Cllento R (1996): Inhibition of monoamine oxidase B in the brains of smokers. Nature 379: 733–736. 10.1038/379733a0 CASPubMedWeb of Science®Google Scholar Grandinetti, A, Morens DM, Reed D, MacEachern D (1994): Prospective study of cigarette smoking and the risk of developing idiopathic Parkinson's disease. Am J Epidemiol 139: 1129–1138. 10.1093/oxfordjournals.aje.a116960 CASPubMedWeb of Science®Google Scholar Grimberg, J, Nawoschik S, Belluscio L, McKee R, Turk A, Eisenberg A (1989): A simple and efficient non-organic procedure for the isolation of genomic DNA from blood. Nucleic Acids Res 17: 8390. 10.1093/nar/17.20.8390 CASPubMedWeb of Science®Google Scholar Ho, SL, Ramsden DB, Kapadi AL, Sturman SG, Williams AC (1994): Activity and polymorphism of monoamine oxidase-B gene in idiopathic Parkinson's disease. Biogenic Amines 10: 579–585. CASWeb of Science®Google Scholar Ho, SL, Kapadi AL, Ramsden DB, Williams AC (1995): An allelic association study of monoamine oxidase B in Parkinson's disease. Ann Neurol 37: 403–405. 10.1002/ana.410370318 CASPubMedWeb of Science®Google Scholar Hsu Y-P, Powell, JF, Sims KB, Breakfield XO (1989): Molecular genetics of monoamine oxidases. J Neurochem 53: 12–18. 10.1111/j.1471-4159.1989.tb07289.x CASPubMedWeb of Science®Google Scholar Konradi, C, Ozelius L, Breakfield XO (1992): Highly polymorphic (GT)n repeating sequence in the intron II of the human MAO-B gene. Genomics 12: 176–177. 10.1016/0888-7543(92)90426-S CASPubMedWeb of Science®Google Scholar Kurth, JH, Kurth MC, Poduslo SE, Schwankhaus JD (1993): Association of a monoamine oxidase B allele with Parkinson's disease. Ann Neurol 33: 368–372. 10.1002/ana.410330406 CASPubMedWeb of Science®Google Scholar Morimoto, Y, Murayama N, Kuwano A, Kondo I, Yamashita Y, Mizuno Y (1995): Association of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population. Am J Med Genet 60: 570–572. 10.1002/ajmg.1320600618 CASPubMedWeb of Science®Google Scholar Nanko, S, Ueki A, Hattori M (1996): No association between Parkinson's disease and monoamine oxidase A and B gene polymorphisms. Neurosci Lett 204: 125–127. 10.1016/0304-3940(95)12298-2 CASPubMedWeb of Science®Google Scholar Riederer, P, Konradi C, Hebestreit G, Youdim MBH (1989): Neurochemical perspectives to the function of monoamine oxidase. Acta Neurol Scand 126: 41–45. 10.1111/j.1600-0404.1989.tb01781.x CASPubMedWeb of Science®Google Scholar SAS Institute, Inc. (1993): " Statistical Analysis System User's Guide, Release 6." Cary, NC: SAS Institute, pp 160–173. Google Scholar Selvin S: (1991): " Statistical Analysis of Epidemiologic Data." New York: Oxford University Press, pp 173–213. Google Scholar Citing Literature Volume74, Issue218 April 1997Pages 154-156 ReferencesRelatedInformation
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