Synthetic studies towards Leinamycin. A concise synthesis of the spiro-fused 1,3-Dioxo-1,2-dithiolane moiety.
1991; Elsevier BV; Volume: 32; Issue: 45 Linguagem: Inglês
10.1016/0040-4039(91)80239-3
ISSN1873-3581
AutoresGerald Pattenden, Anthony J. Shuker,
Tópico(s)Macrophage Migration Inhibitory Factor
ResumoA synthesis of the 1,3-dioxo-1,2-dithiolabne residue (2) found in the antitumour antibiotic substance leinamycin (1) is described which features: (i) elaboration of the thiolactone (5), followed by (ii) ring opening to the thioacid (9) using H2S-Et3N and (iii) ring closure of (9) to (4) in the presence of aq. FeCl3, and finally (iv) oxidation (Scheme 1). 30071991
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