Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Profilaxia intermitente na convulsão febril com diazepam via oral

1992; Thieme Medical Publishers (Germany); Volume: 50; Issue: 2 Linguagem: Inglês

10.1590/s0004-282x1992000200005

1678-4227

Marilisa M. Guerreiro, Maristela Costa, M. Angela Bellomo, Sílvia H. Sabino, Ednéa A. Silva, ANNA ELISA SCOTONI,

Pharmacological Effects and Toxicity Studies

Intermittent prophylaxis with oral diazepam is presented as an optional treatment for febrile seizures. This proposition is justified by the severe side effects of the currently used chronic anticonvulsant drug therapy in febrile seizures (phenobarbital and valproate). Nineteen patients aged between 3 months and 5 years were treated. They had either simple or complex febrile seizures. Sixteen patients had at least one prognostic factor for recurrence of febrile seizures: first febrile seizure before 15 months of age, positive family history for epilepsy or febrile seizures, occurrence of a complex febrile seizure or abnormal neurological examination. Three patients had none (cases 8, 12 and 13). We recommended 2.5mg b.i.d. for children younger than 12 months, 5mg b.i.d. for children older than 12 months and younger than 3 years, and 7.5 b.i.d. for children older than 3 years. The results showed that only one patient had febrile convulsions while taking adequate diazepam dosage. Transient side effects occurred in 36.8% of the cases.