Treatment results with fermented mistletoe (Viscum album L.) extract as part of long-term supportive care in patients with primary non- metastatic colorectal carcinoma
2008; Elsevier BV; Volume: 6; Issue: 9 Linguagem: Inglês
10.1016/s1359-6349(08)71709-9
ISSN1878-1217
AutoresE Friedel, Harald Matthes, P.R. Bock,
Tópico(s)Porphyrin Metabolism and Disorders
ResumoMistletoe lectin is a potent biohazard. Lectin activity in the toxic dimer primarily originates from the 2γ-subdomain (Tyr-site) of the B-subunit. Crystallographic information on lectin–sugar complexes is available only at acidic pH, where lectin activity is low. Thus, we mapped ligand-binding properties including comparison to ricin’s Tyr-site at neutral pH. Using these results and molecular dynamics simulations, a local conformational change was rendered likely. The obtained structural information is valuable for the design of potent inhibitors.
Referência(s)