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AA genotype of single‐nucleotide polymorphism c.834+7 G > A in GAS 6 gene (rs8191974) is not protective for acute myocardial infarction

2013; Wiley; Volume: 35; Issue: 5 Linguagem: Inglês

10.1111/ijlh.12055

1751-553X

Didier Jambou, M Candito, Pascal Staccini, Anny Appert‐Flory, Florence Fischer, Pierre Gibelin, Pierre Toulon,

Biomarkers in Disease Mechanisms

International Journal of Laboratory HematologyVolume 35, Issue 5 p. e17-e20 Letter to the Editor AA genotype of single-nucleotide polymorphism c.834+7G>A in GAS6 gene (rs8191974) is not protective for acute myocardial infarction D. Jambou, D. Jambou [email protected] Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorM. Candito, M. Candito Laboratoire de Biochimie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Staccini, P. Staccini Département d'Information et Informatique Médicale, Hôpital de Cimiez, CHU de Nice, Nice, FranceSearch for more papers by this authorA. Appert-Flory, A. Appert-Flory Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorF. Fischer, F. Fischer Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Gibelin, P. Gibelin Service de Cardiologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Toulon, P. Toulon Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this author D. Jambou, D. Jambou [email protected] Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorM. Candito, M. Candito Laboratoire de Biochimie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Staccini, P. Staccini Département d'Information et Informatique Médicale, Hôpital de Cimiez, CHU de Nice, Nice, FranceSearch for more papers by this authorA. Appert-Flory, A. Appert-Flory Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorF. Fischer, F. Fischer Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Gibelin, P. Gibelin Service de Cardiologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this authorP. Toulon, P. Toulon Laboratoire d'Hématologie, Hôpital Pasteur, CHU de Nice, Nice, FranceSearch for more papers by this author First published: 19 February 2013 https://doi.org/10.1111/ijlh.12055Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1Manfioletti G, Brancolini C, Avanzi G, Schneider C. The protein encoded by a growth arrest-specific gene (GAS 6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol 1993; 13: 4976–85. 2Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ. Characterization of GAS6, a member of the Superfamily of G domain-containing proteins, as a ligand for Rse and Axl. J Biol Chem 1996; 271: 9785–9. 3Fernández-Fernández L, Bellido-Martín L, García de Frutos P. Growth arrest-specific gene 6 (GAS 6). An outline of its role in haemostasis and inflammation. Thromb Haemost 2008; 100: 604–10. 4Tjwa M, Bellido-martin L, Lin Y, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billian AD, Aparicio C, Levi M, Daeman M, Dewerchin M, Lupu F, Arnout J, Hebert JM, Waer M, De Frutos PG, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L. GAS6 promotes inflammation by enhancing interactions between endothelial cells, platelets and leucocytes. Blood 2008; 111: 4096–105. 5Cosemans JMEM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix CA, Walterberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk WM. Potentiated role of GAS6 and TYRO3, AXL and MER (TAM) receptors in human and murine platelets activation and thrombus stabilization. J Thromb Haemost 2010; 8: 1797–808. 6Lemke G, Burstyn-Cohen T. TAM receptors and the clearance of apoptotic cells. Ann N Y Acad Sci 2010; 1209: 23–9. 7Munoz X, Sumoy L, Ramírez-Lorca R, Villar J, De Frutos PG, Sala N. Human vitamin K-dependant gas 6: gene structure, allelic variation, and association with stroke. Hum Mutat 2004; 23: 506–12. 8Munoz X, Obach V, Hurtado B, De Frutos PG, Chamorro A, Sala N. Association of specific haplotypes of GAS 6 gene with stroke. Thromb Haemost 2007; 98: 406–12. 9Jiang L, Liu CY, Yang QF, Wang P, Zhang W. Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in patients with acute coronary syndrome. Am J Clin Pathol 2009; 131: 738–43. 10Hurtado B, Abasolo N, Munoz X, Garcia N, Benavente Y, Rubio F, De Frutos PG, Krupinski J, Sala N. Association study between polymorphism in GAS6-TAM genes and carotid atherosclerosis. Thromb Haemost 2010; 104: 592–8. Citing Literature Volume35, Issue5October 2013Pages e17-e20 ReferencesRelatedInformation