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Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer

2006; Lippincott Williams & Wilkins; Volume: 175; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(05)00659-2

1527-3792

Changyi Quan, Eun‐Jong Cha, Hyung-Lae Lee, Kwang Hee Han, Keon Myung Lee, Wun‐Jae Kim,

Genomics, phytochemicals, and oxidative stress

No AccessJournal of UrologyInvestigative urology1 Apr 2006Enhanced Expression of Peroxiredoxin I and VI Correlates with Development, Recurrence and Progression of Human Bladder Cancer Changyi Quan, Eun-Jong Cha, Hyung-Lae Lee, Kwang Hee Han, Keon Myung Lee, and Wun-Jae Kim Changyi QuanChangyi Quan Department of Urology, Yanbian University Hospital, Yanji, People's Republic of China , Eun-Jong ChaEun-Jong Cha Department of Biomedical Engineering, Chungbuk National University, Cheongju, South Korea , Hyung-Lae LeeHyung-Lae Lee Department of Urology, Chungbuk National University, Cheongju, South Korea , Kwang Hee HanKwang Hee Han Department of Urology, Chungbuk National University, Cheongju, South Korea , Keon Myung LeeKeon Myung Lee College of Medicine and School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, South Korea , and Wun-Jae KimWun-Jae Kim Department of Urology, Chungbuk National University, Cheongju, South Korea Institute for Tumor Research, Chungbuk National University, Cheongju, South Korea View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00659-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: PRDXs are antioxidant enzymes that have an important role in cell differentiation, proliferation and apoptosis. We investigated whether PRDX I and VI expression is related to bladder cancer. Materials and Methods: PRDX I and VI mRNA levels were examined in 149 tumor specimens in patients with primary bladder cancer, in 19 specimens with corresponding normal-appearing bladder mucosa surrounding cancer and in 18 with normal bladder mucosa using real-time polymerase chain reaction. Results: PRDX I and VI expression in bladder cancer (0.6644 and 0.1455 pg/ml) was significantly higher than in normal tissue (0.0278 and 0.0542 pg/ml, each p <0.05) and higher than in corresponding normal bladder mucosa surrounding cancer (0.2353 and 0.0304 pg/ml, respectively, each p <0.0005). PRDX I and VI expression was enhanced in patients with no recurrence (0.8148 and 0.2232 pg/ml) and no progression (0.7405 and 0.1716 pg/ml) compared with levels in those with recurrence (0.4314 and 0.0588 pg/ml) and progression (0.4338 and 0.0668 pg/ml, respectively, each p <0.05). PRDX I and VI expression did not correlate with disease-free survival in patients with bladder cancer. Conclusions: Enhanced PRDX I and VI expression is strongly associated with bladder cancer development. Moreover, enhanced PRDX I and VI expression is also positively associated with a low rate of bladder cancer recurrence and progression. It might be useful as a marker for assessing the recurrence or progression of human bladder cancer. References 1 : Urothelial tumors of the urinary tract. In: Campbell's Urology. Edited by . Philadelphia: W. B. Saunders Co2002: 2750. vol. 4, sect. X, chapt. 76. Google Scholar 2 : Relationship of dietary vitamin A and ascorbic acid intake to the risk for cancers of the lung, bladder, and prostate in Hawaii. Natl Cancer Inst Monogr1985; 69: 137. Google Scholar 3 : Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen. Jpn J Cancer Res2002; 93: 736. 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Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4April 2006Page: 1512-1516 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsbladderbladder neoplasmsperoxiredoxintumor markersbiologicalenzymesMetricsAuthor Information Changyi Quan Department of Urology, Yanbian University Hospital, Yanji, People's Republic of China More articles by this author Eun-Jong Cha Department of Biomedical Engineering, Chungbuk National University, Cheongju, South Korea More articles by this author Hyung-Lae Lee Department of Urology, Chungbuk National University, Cheongju, South Korea More articles by this author Kwang Hee Han Department of Urology, Chungbuk National University, Cheongju, South Korea More articles by this author Keon Myung Lee College of Medicine and School of Electrical and Computer Engineering, Chungbuk National University, Cheongju, South Korea More articles by this author Wun-Jae Kim Department of Urology, Chungbuk National University, Cheongju, South Korea Institute for Tumor Research, Chungbuk National University, Cheongju, South Korea More articles by this author Expand All Advertisement PDF DownloadLoading ...