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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Pulmonary emphysema induced by passive smoking: an experimental study in rats

1997; Associação Brasileira de Divulgação Científica; Volume: 30; Issue: 10 Linguagem: Inglês

10.1590/s0100-879x1997001000017

ISSN

1414-431X

Autores

Sônia Cendon, Cláudia Naves Battlehner, Geraldo Lorenzi‐Filho, Marisa Dohlnikoff, Priscilla Maria Rodrigues Pereira, Gleice M.S. Conceição, Osvaldo Shigueomi Beppu, Paulo Hilário Nascimento Saldiva,

Tópico(s)

Respiratory Support and Mechanisms

Resumo

We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78; P<0.05). When the two groups of smoking rats were pooled together and compared to controls, they showed decreased lung elastance (1.6 vs 2.19; P = 0.046) and increased mean linear intercept (Lm) (85.14 vs 66.44; P = 0.025). The s-90 animals presented higher inflammation and muscular hypertrophy at the level of the axial bronchus than the controls (P<0.05). When smoking groups were pooled and compared to controls, they presented significantly higher inflammation at the lateral level (P = 0.028), as well as airway secretory hyperplasia (P = 0.024) and smooth muscle hypertrophy (P = 0.005) at the axial level. Due to its simplicity, low cost and short duration, this technique may be a useful model to obtain new information about airspace remodeling due to chronic tobacco consumption

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