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Highly Chemoselective Reduction of Aromatic Nitro Compounds by Copper Nanoparticles/Ammonium Formate

2008; American Chemical Society; Volume: 73; Issue: 17 Linguagem: Inglês

10.1021/jo800863m

1520-6904

Amit Saha, Brindaban C. Ranu,

Innovative Microfluidic and Catalytic Techniques Innovation

A highly chemoselective reduction of aromatic nitro compounds to the corresponding amino derivatives has been achieved by a combination of copper nanoparticles and ammonium formate in ethylene glycol at 120 °C. The reductions are successfully carried out in presence of a wide variety of other reducible functional groups in the molecule, such as Cl, I, OCH2Ph, NHCH2Ph, COR, COOR, CN, etc. The reactions are very clean and high yielding.