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Consistent Reversible Elevations of Serum Creatinine Levels in Severe Hypothyroidism

1999; American Medical Association; Volume: 159; Issue: 1 Linguagem: Inglês

10.1001/archinte.159.1.79

1538-3679

Stuart H. Kreisman, James V. Hennessey,

Thyroid Disorders and Treatments

Background: Changes in routine clinical chemical indicators of renal function in the hypothyroid state are not well characterized, and are infrequently discussed in standard internal medicine or subspeciality textbooks.Patients and Methods: We evaluated 24 consecutive patients with iatrogenic hypothyroidism induced prior to radioiodine scanning for monitoring of thyroid carcinoma.Serum creatinine and thyroid function tests were measured prior to, during, and subsequent to the period of induced hypothyroidism.Results: Among 29 episodes with paired prior euthyroid and hypothyroid serum creatinine values, the hypothyroid value was greater in 26 (89.7%), and equal in 3 (10.3%),less in none; the mean hypothyroid value was significantly greater (103 vs 76 µmol/L [1.17 vs 0.87 mg/