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HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation

2014; Elsevier BV; Volume: 124; Issue: 26 Linguagem: Inglês

10.1182/blood-2014-09-599969

1528-0020

Effie W. Petersdorf, Theodore A. Gooley, Mari Malkki, Andrea Bacigalupo, Anne Cesbron, E. D. du Toit, Gerhard Ehninger, Torstein Egeland, Gottfried Fischer, Thibaut Gervais, Michael Haagenson, Mary M. Horowitz, Katharine C. Hsu, Pavel Jindra, J. Alejandro Madrigal, Machteld Oudshoorn, Olle Ringdén, Marlis L. Schroeder, Stephen R. Spellman, J.-M. Tiercy, Andrea Velardi, Campbell S. Witt, Colm Ó’hUigín, Richard Apps, Mary Carrington,

T-cell and B-cell Immunology

Key Points The expression level of patient HLA-C allotypes affects GVHD and mortality after HCT from HLA-C-mismatched unrelated donors. Transplant outcome can be improved by avoiding high-risk HLA-C-mismatched donors when no matched stem cell source is available.