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A study of inbreeding and kinship in intracranial aneurysms in the Saguenay Lac‐Saint‐Jean region (Quebec, Canada)

1996; Wiley; Volume: 60; Issue: 2 Linguagem: Inglês

10.1111/j.1469-1809.1996.tb01181.x

1469-1809

Marc De Braekeleer, Louis Pérusse, Mario Cantín, Jean-Marie Bouchard, Jean Mathieu,

Intracranial Aneurysms: Treatment and Complications

Summary The genealogies of 533 individuals with an intracranial aneurysm (IA) born in the Saguenay‐Lac‐Saint‐Jean region, a geographically isolated area located in northeastern Quebec, were reconstructed using a population‐based register. A control group consisting of three individuals of the same sex and born on the same day and in the same municipality than the IA patients was created; the genealogies of the 1599 controls were also reconstructed. The coefficients of inbreeding and kinship were calculated. Familial aggregation, i.e. the presence of IA in two or more first‐ to third‐degree relatives, was also sought. The mean inbreeding coefficient was lower in the IA group than in the control group (7·92 × 10 −4 versus 10·04 × 10 −4 ). The mean kinship coefficient was higher in the IA group than in the control group (2·17 × 10 −4 versus 1·55 × 10 −4 ). Forty‐eight IA patients (9·0%) were first‐degree relatives compared to only 1·9% of the control individuals. The proportion of individuals showing familial aggregation was higher in the IA group than in the control group (29·8% and 18·6% respectively). These results strongly suggest that some IA are genetically determined in this population.