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Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx

2005; Wiley; Volume: 27; Issue: 3 Linguagem: Inglês

10.1002/hed.20149

1097-0347

R. Kania, Dana M. Hartl, Cécile Badoual, Christine Le Maignan, Daniel Brasnu,

Eosinophilic Disorders and Syndromes

Mucosa-associated lymphoid tissue (MALT) lymphoma is usually associated with a chronic inflammatory disease from which lymphoid tissue of MALT type arises as a prerequisite for lymphoma proliferation. No well-characterized chronic inflammatory process has been identified in the larynx.We report a case of primary MALT lymphoma of the larynx associated with extraesophageal reflux, chronic laryngitis, and gastric Helicobacter pylori infection, raising the issue of its physiopathology and treatment.Treatment of this MALT lymphoma of the larynx consisted of complete surgical excision associated with omeprazole, amoxicillin, and clarithromycin. No evidence of disease was observed after 24 months of follow-up.We may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H. pylori infection.