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Short Communication: Human Lymphotropic Virus Type 1 Coinfection Modulates the Synthesis of Cytokines by Peripheral Blood Mononuclear Cells from HIV Type 1-Infected Individuals

2011; Mary Ann Liebert, Inc.; Volume: 28; Issue: 8 Linguagem: Inglês

10.1089/aid.2011.0192

ISSN

1931-8405

Autores

Marcos Herculano Nunes Abrahão, Rosangela G. Lima, Eduardo Martins Netto, Carlos Brites,

Tópico(s)

Animal Disease Management and Epidemiology

Resumo

HIV-1 and HTLV-1 infect CD4+ T lymphocyte but little is known about the impact of coinfection on patient's immune response. In this study we have evaluated the spontaneous production of interleukin (IL)-2, IL-4, IL-6, and IL-10 and interferon (IFN)-γ by unstimulated peripheral blood mononuclear cell (PBMC) cultures obtained from patients infected by HTLV-1, HIV-1, or both viruses. We have observed that HIV/HTLV-coinfected individuals presented significantly higher production of IL-2 and IFN-γ compared to both HIV single-infected and HTLV single-infected individuals. IL-6 and IL-10 synthesis was similar in all infected groups, but HTLV single-infected individuals presented a lower production of IL-4. These results show that HIV/HTLV-coinfected individuals presented a profile of higher production of Th-1 cytokines, suggesting a predominant stimulus of HTLV-1 in detriment to HIV-1 infection.

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