Structure and function of the skeletal muscle extracellular matrix
2011; Wiley; Volume: 44; Issue: 3 Linguagem: Inglês
10.1002/mus.22094
ISSN1097-4598
AutoresAllison R. Gillies, Richard L. Lieber,
Tópico(s)Muscle activation and electromyography studies
ResumoThe skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure–function relationships. Detailed structure–function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study.
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