Produção Nacional
Revisado por pares
Synthesis and antituberculosis activity of new fatty acid amides
2010; Elsevier BV; Volume: 20; Issue: 17 Linguagem: Inglês
10.1016/j.bmcl.2010.06.149
ISSN1464-3405
AutoresCaroline Da Ros Montes D’Oca, Tatiane S. Coelho, Tamara Germani Marinho, Carolina R. L. Hack, Rodrigo da Costa Duarte, Pedro Eduardo Almeida da Silva, Marcelo G. Montes D’Oca,
Tópico(s)GABA and Rice Research
ResumoThis work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 μg/mL for resistance strains.
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