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Observations on electrical stimulation of the cerebellar cortex

1929; Royal Society; Volume: 104; Issue: 733 Linguagem: Inglês

10.1098/rspb.1929.0023

2053-9185

D. Denny‐Brown, J. C. Eccles, E. G. T. Liddell,

Ophthalmology and Eye Disorders

In recent years Miller (8) and fulton (6) among other authors have produced valuable reviews of the question of cerebellar function. Of primary importance in investigating cerebellar activity by stimulation of its cortex is the fundamental observation of Sherrington (12) that faradisation of the rostral surface produces ipsilateral inhibition of inhibition of decerebrate rigidity. Latterly this observation has been confirmed and amplified by Bremer (1) and by Miller and Banting (7) among others. Electrical stimulation of the anterior lobe inhibits posture in ipsilateral antigravity muscles augments lobe produces spasticity of antigravity muscles on one or both sides. In the pigeon, Which lacks a pyramidal tract, Bremer and Ley (2) Have obtained similar results by excision of, or by stimulation of, the cerebellar cortes. Pollock and Davis (10) have produced similar results in cats by rendering anæmic the anterior part of the cerebellum at the same time as the precollicular neuraxis. Rademaker's animals, from which the entire cerebellum had been ablated, were observed for many months(11) and throughout that time hypertonicity of antigravity muscles was a prominent feature of their symptoms. More recently, Miller and Laughton (9) have described the result of stimulating, not the cerebellar cortex, but the nuclei themselves, which were exposed by ablation of overlying nerve tissue. We proposed therefore to extend these observations by use of a dead-beat recording mechanism, namely, the Sherrington myograph.